Prevalence and Patterns of Gene Mutations Associated with <i>M. tuberculosis</i> Resistance to Isoniazid and Rifampicin in Patients with Different Clinical Manifestations of Tuberculosis

The objective : to study prevalence and patterns of mutations in the katG, inhA, ahpC, rpoB genes associated with Mycobacterium tuberculosis (MTB) resistance isoniazid (H) rifampicin (R) patients various clinical manifestations pulmonary (TB). Subjects Methods . 441 sputum samples collected were tested using biological microchips. Tests carried out Group 1 - confirmed bacterial excretion (n = 256) 2 185) without excretion. same enrolled 3 acute progressing 52) 4 99) localized tuberculosis. Results In 1, DNA was found 79.3% patients, 57.8%. Among all samples, encoding detected 15.5%, 58.1%. Resistance more often caused by katG gene (49%) versus inhA (29%) ahpC (4.2%) genes. We 13 most common types rifampicin. dominant both groups Seu531->Leu 19.7% 24.3% 2. (53.7%) observed than (27.7%). 3, registered 30.8%, 25%. There no statistically significant differences between Groups 4. Thus, are a hidden dangerous reservoir tuberculous mycobacteria multiple drug isoniazid.